Mouse Actinin Alpha 2 (ACTN2) Protein

Este producto es parte de ACTN - Actinin Alpha
Mouse Actinin Alpha 2 (ACTN2) Protein

Pida mas información

935106861

info@markelab.com

Precio

2041€ (1 mg)

Protein ACTN2

proveedor

Abbexa

reference

abx065115

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Actinin Alpha 2 (ACTN2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

ACTN2 encodes alpha-actinin-2, a muscle-specific isoform of the actinin family, expressed predominantly in cardiac and skeletal muscle tissues. It functions as a structural component of the sarcomere, anchoring actin filaments to the Z-discs and contributing to the maintenance of sarcomere integrity during muscle contraction. ACTN2 also plays a role in signal transduction by interacting with a variety of signaling and cytoskeletal proteins, modulating muscle development and repair. Mutations in ACTN2 are associated with cardiomyopathies, including hypertrophic and dilated cardiomyopathy, where impaired sarcomeric organization leads to reduced cardiac function. Its critical role in sarcomere structure and interaction with signaling pathways highlights its importance in maintaining muscle function and responding to mechanical stress.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Actinin Alpha 2 (ACTN2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

1 mg


size 2

5 mg


observerd MW

Molecular Weight: Calculated MW: 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-His254 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ACTN2


dry ice

No


availability

Shipped within 1-2 months.


alias

ACTN2,CMD1AA,CMH23,MYOCOZ,MPD6


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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