Mouse Actinin Alpha 2 (ACTN2) Protein
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935106861
info@markelab.com
Precio
2041€ (1 mg)
Protein ACTN2
proveedor
Abbexareference
abx065115Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Actinin Alpha 2 (ACTN2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
ACTN2 encodes alpha-actinin-2, a muscle-specific isoform of the actinin family, expressed predominantly in cardiac and skeletal muscle tissues. It functions as a structural component of the sarcomere, anchoring actin filaments to the Z-discs and contributing to the maintenance of sarcomere integrity during muscle contraction. ACTN2 also plays a role in signal transduction by interacting with a variety of signaling and cytoskeletal proteins, modulating muscle development and repair. Mutations in ACTN2 are associated with cardiomyopathies, including hypertrophic and dilated cardiomyopathy, where impaired sarcomeric organization leads to reduced cardiac function. Its critical role in sarcomere structure and interaction with signaling pathways highlights its importance in maintaining muscle function and responding to mechanical stress.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Actinin Alpha 2 (ACTN2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Molecular Weight: Calculated MW: 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-His254 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ACTN2
dry ice
No
availability
Shipped within 1-2 months.
alias
ACTN2,CMD1AA,CMH23,MYOCOZ,MPD6
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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