Mouse Actinin Alpha 2 (ACTN2) Protein
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Description
Recombinant Actinin Alpha 2 (ACTN2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Actinin Alpha 2 (ACTN2) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-His254 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9JI91 |
| Alias | ACTN2,CMD1AA,CMH23,MYOCOZ,MPD6 |
| Background | Protein ACTN2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ACTN2 encodes alpha-actinin-2, a muscle-specific isoform of the actinin family, expressed predominantly in cardiac and skeletal muscle tissues. It functions as a structural component of the sarcomere, anchoring actin filaments to the Z-discs and contributing to the maintenance of sarcomere integrity during muscle contraction. ACTN2 also plays a role in signal transduction by interacting with a variety of signaling and cytoskeletal proteins, modulating muscle development and repair. Mutations in ACTN2 are associated with cardiomyopathies, including hypertrophic and dilated cardiomyopathy, where impaired sarcomeric organization leads to reduced cardiac function. Its critical role in sarcomere structure and interaction with signaling pathways highlights its importance in maintaining muscle function and responding to mechanical stress.
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