Mouse Acetylcholinesterase (AChE) Protein (Active)
871€ (20 µg)
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name
Mouse Acetylcholinesterase (AChE) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691917
tested applications
SDS-PAGE
Description
Mouse Acetylcholinesterase Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse ACHE (NP_033729.1) (Met 1-Leu 614) was expressed, with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Acetylcholinesterase (AChE) |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 66.2 kDa Sequence Fragment: Met1-Leu614 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 20 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_033729.1 |
| Alias | YT,ACEE,ARACHE,N-ACHE |
| Background | Protein AChE |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Acetylcholinesterase (AChE) is an enzyme that plays a critical role in the nervous system by breaking down the neurotransmitter acetylcholine. AChE is a globular protein, typically found as a tetramer composed of four subunits. Each subunit contains a catalytic site responsible for the enzymatic breakdown of acetylcholine. Acetylcholine is involved in transmitting signals across synapses, which are the gaps between nerve cells. After acetylcholine has transmitted its signal, AChE rapidly breaks it down into its constituent parts: choline and acetate. This breakdown process is crucial for terminating the signal transmission and allowing the nerve cell to return to its resting state . AChE is found primarily at cholinergic synapses, where acetylcholine is released as a neurotransmitter. These synapses are abundant in the central nervous system (CNS) and the peripheral nervous system (PNS). At neuromuscular junctions, AChE is particularly important for allowing muscles to relax after contraction. When a motor neuron releases acetylcholine to signal muscle contraction, AChE quickly degrades the acetylcholine, allowing the muscle to relax. AChE activity can be regulated through various mechanisms, including gene expression, post-translational modifications, and interactions with other proteins. Dysregulation of AChE activity has been implicated in various neurological disorders, including Alzheimer's disease and myasthenia gravis.
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