Family main features
Acetylcholinesterase (AChE) is an enzyme that plays a critical role in the nervous system by breaking down the neurotransmitter acetylcholine. AChE is a globular protein, typically found as a tetramer composed of four subunits. Each subunit contains a catalytic site responsible for the enzymatic breakdown of acetylcholine. Acetylcholine is involved in transmitting signals across synapses, which are the gaps between nerve cells. After acetylcholine has transmitted its signal, AChE rapidly breaks it down into its constituent parts: choline and acetate. This breakdown process is crucial for terminating the signal transmission and allowing the nerve cell to return to its resting state . AChE is found primarily at cholinergic synapses, where acetylcholine is released as a neurotransmitter. These synapses are abundant in the central nervous system (CNS) and the peripheral nervous system (PNS). At neuromuscular junctions, AChE is particularly important for allowing muscles to relax after contraction. When a motor neuron releases acetylcholine to signal muscle contraction, AChE quickly degrades the acetylcholine, allowing the muscle to relax. AChE activity can be regulated through various mechanisms, including gene expression, post-translational modifications, and interactions with other proteins. Dysregulation of AChE activity has been implicated in various neurological disorders, including Alzheimer's disease and myasthenia gravis.
AChE has a complex structure that includes:
AChE can be classified based on its tissue-specific expression and structural variants:
AChE performs several critical functions:
AChE interacts with various molecules and proteins in the nervous system:
The activity of AChE and its regulation are critical in several clinical contexts:
AChE is an essential enzyme responsible for the hydrolysis of acetylcholine, playing a critical role in terminating neurotransmission at cholinergic synapses. It has a complex structure, including a catalytic domain and peripheral anionic site, and exists in various forms depending on the tissue. AChE's function is vital for neuromuscular function, cognitive processes, and overall neural communication. It interacts with substrates, inhibitors, structural subunits, and pathological peptides. Clinically, AChE is significant in the context of Alzheimer's disease, myasthenia gravis, organophosphate poisoning, and other neurological disorders. Understanding AChE's structure, function, interactions, and clinical implications provides valuable insights into its role in health and disease and highlights potential therapeutic targets.
Acetylcholinesterase(AChE)
YT,ACEE,ARACHE,N-ACHE
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | AChE | ECH0016 | Chicken Ache(Acetylcholinesterase) ELISA Kit | chicken | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 1.563-100ng/ml | 96T | P36196 | RUO | ||
Abbexa | AChE | abx357139 | Chicken Acetylcholinesterase (AChE) ELISA Kit | Chicken | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 7.81 ng/ml - 500 ng/ml | 4.69 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | AChE | abx515700 | Cow Acetylcholinesterase (AChE) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.34 ng/ml | 687.5 | 96 tests | P23795 | RUO |
FineTest | AChE | EH1362 | Human ACHE(Acetylcholinesterase) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 1.563-100ng/ml | 96T | P22303 | RUO | ||
Abbexa | AChE | abx250633 | Human Acetylcholinesterase (AChE) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.63 IU/ml - 1000 IU/ml | 9.38 IU/ml | 525 | 96 tests | P22303 | RUO |
Abbexa | AChE | abx150521 | Human Acetylcholinesterase (AChE) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.27 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | AChE | abx195037 | Human Acetylcholinesterase (AChE) CLIA Kit | Human | Tissue homogenates, cell lysates, and other biological fluids. | Sandwich | 0.31 ng/ml - 20 ng/ml | 0.19 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | AChE | abx492758 | Human Acetylcholinesterase (AChE) CLIA Kit | Human | Tissue homogenates, cell lysates, and other biological fluids. | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.21 ng/ml | 812.5 | 96 tests | RUO | |
FineTest | AChE | EM0540 | Mouse Ache(Acetylcholinesterase) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.781-50ng/ml | 96T | P21836 | RUO | ||
Abbexa | AChE | abx492759 | Mouse Acetylcholinesterase (AChE) CLIA Kit | Mouse | Tissue homogenates, cell lysates, and other biological fluids. | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.28 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | AChE | abx153588 | Mouse Acetylcholinesterase (AChE) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.28 ng/ml | 675 | 96 tests | RUO | |
Abbexa | AChE | abx573651 | Mouse Acetylcholinesterase (AChE) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 525 | 96 tests | P21836 | RUO |
Abbexa | AChE | abx363773 | Rabbit Acetylcholinesterase (AChE) ELISA Kit | Rabbit | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 7.81 ng/ml - 500 ng/ml | 4.69 ng/ml | 662.5 | 96 tests | RUO | |
FineTest | AChE | ER0461 | Rat Ache(Acetylcholinesterase) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.781-50ng/ml | 96T | P37136 | RUO | ||
Abbexa | AChE | abx492760 | Rat Acetylcholinesterase (AChE) CLIA Kit | Rat | Tissue homogenates, cell lysates, and other biological fluids. | Sandwich | 0.781 ng/ml - 50 ng/ml | < 0.34 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | AChE | abx496323 | Rat Acetylcholinesterase (AChE) CLIA Kit | Rat | Tissue homogenates, cell lysates, and other biological fluids. | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.23 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | AChE | abx258732 | Rat Acetylcholinesterase (AChE) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.23 ng/ml | 675 | 96 tests | RUO | |
Abbexa | AChE | abx195038 | Rat Acetylcholinesterase (AChE) CLIA Kit | Rat | Tissue homogenates, cell lysates, and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | AChE | abx155133 | Rat Acetylcholinesterase (AChE) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.34 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | AChE | abx256439 | Rat Acetylcholinesterase (AChE) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.63 ng/ml - 40 ng/ml | 0.38 ng/ml | 531.25 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AChE | abx107655 | Acetylcholinesterase (AChE) Antibody (FITC) | Cow | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | FITC | 162.5 | 20 µg | P23795 | RUO | ||
Abbexa | AChE | abx110522 | Acetylcholinesterase (AChE) Antibody | Cow | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA | 162.5 | 20 µg | P23795 | RUO | |
Abbexa | AChE | abx106241 | Acetylcholinesterase (AChE) Antibody (Biotin) | Cow | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Biotin | ELISA | 162.5 | 20 µg | P23795 | RUO | |
Abbexa | AChE | abx109072 | Acetylcholinesterase (AChE) Antibody (HRP) | Cow | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | HRP | ELISA | 162.5 | 20 µg | P23795 | RUO | |
FineTest | AChE | FNab00083 | anti- ACHE antibody | human | polyclonal | Rabbit | acetylcholinesterase (Yt blood group) | IgG | Unconjugated | ELISA, WB, IHC | 100µg | P22303 | RUO | |
Abbexa | AChE | abx033719 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 250 | 80 µl | P22303 | RUO | |
Abbexa | AChE | abx345931 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P22303 | RUO | |
Abbexa | AChE | abx432271 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Goat | Acetylcholinesterase (AChE) | Unconjugated | P-ELISA, WB, IF/ICC, FCM | 387.5 | 200 µl | RUO | ||
Abbexa | AChE | abx272138 | Acetylcholinesterase (AChE) Antibody (Biotin) | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | AChE | abx345934 | Acetylcholinesterase (AChE) Antibody (Biotin) | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Biotin | ELISA | 162.5 | 20 µg | P22303 | RUO | |
Abbexa | AChE | abx101933 | Acetylcholinesterase (AChE) Antibody | Human | Monoclonal | Mouse | Acetylcholinesterase (AChE) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | AChE | abx345933 | Acetylcholinesterase (AChE) Antibody (FITC) | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | FITC | 162.5 | 20 µg | P22303 | RUO | ||
Abbexa | AChE | abx345932 | Acetylcholinesterase (AChE) Antibody (HRP) | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | HRP | ELISA | 162.5 | 20 µg | P22303 | RUO | |
Abbexa | AChE | abx101930 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P22303 | RUO | |
Abbexa | AChE | abx230083 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P22303 | RUO | |
Abbexa | AChE | abx110745 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P22303 | RUO | |
Abbexa | AChE | abx214081 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P22303 | RUO | |
Abbexa | AChE | abx328808 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P22303 | RUO | |
Abbexa | AChE | abx327969 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P22303 | RUO | |
Abbexa | AChE | abx214328 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB | 250 | 50 µl | P22303 | RUO | |
Abbexa | AChE | abx005992 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | WB, IF/ICC | 175 | 20 µl | P22303 | RUO | |
Abbexa | AChE | abx014143 | Acetylcholinesterase (AChE) Antibody | Human | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB | 43.75 | 10 µg | P22303 | RUO | |
Abbexa | AChE | abx034995 | Acetylcholinesterase (AChE) Antibody | Human | Monoclonal | Mouse | Acetylcholinesterase (AChE) | Unconjugated | ELISA, WB | 281.25 | 80 µl | P22303 | RUO | |
Abbexa | AChE | abx376484 | Acetylcholinesterase (AChE) Antibody | Human | Monoclonal | Mouse | Acetylcholinesterase (AChE) | 2187.5 | 1 mg | P22303 | RUO | |||
Abbexa | AChE | abx101931 | Acetylcholinesterase (AChE) Antibody | Mouse | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P21836 | RUO | |
Abbexa | AChE | abx272988 | Acetylcholinesterase (AChE) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Biotin | WB, IHC, IF/ICC | 375 | 200 µl | RUO | ||
Abbexa | AChE | abx101932 | Acetylcholinesterase (AChE) Antibody | Mouse | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P21836 | RUO | |
Abbexa | AChE | abx101934 | Acetylcholinesterase (AChE) Antibody | Rat | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P37136 | RUO | |
Abbexa | AChE | abx273254 | Acetylcholinesterase (AChE) Antibody (Biotin) | Rat | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Biotin | WB, IHC, IF/ICC | 375 | 200 µl | RUO | ||
Abbexa | AChE | abx101935 | Acetylcholinesterase (AChE) Antibody | Rat | Polyclonal | Rabbit | Acetylcholinesterase (AChE) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P37136 | RUO | |
Abbexa | AChE | abx348842 | Acetylcholinesterase (ache) Antibody (Biotin) | Zebrafish | Polyclonal | Rabbit | Acetylcholinesterase (ache) | Biotin | ELISA | 162.5 | 20 µg | Q9DDE3 | RUO | |
Abbexa | AChE | abx348841 | Acetylcholinesterase (ache) Antibody (FITC) | Zebrafish | Polyclonal | Rabbit | Acetylcholinesterase (ache) | FITC | 162.5 | 20 µg | Q9DDE3 | RUO | ||
Abbexa | AChE | abx348839 | Acetylcholinesterase (ache) Antibody | Zebrafish | Polyclonal | Rabbit | Acetylcholinesterase (ache) | Unconjugated | ELISA, WB | 162.5 | 20 µg | Q9DDE3 | RUO | |
Abbexa | AChE | abx348840 | Acetylcholinesterase (ache) Antibody (HRP) | Zebrafish | Polyclonal | Rabbit | Acetylcholinesterase (ache) | HRP | ELISA | 162.5 | 20 µg | Q9DDE3 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AChE | abx065083 | Human Acetylcholinesterase (AChE) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P22303 | RUO |
Abbexa | AChE | abx065084 | Rat Acetylcholinesterase (AChE) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2525 | 1 mg | P37136 | RUO |
Abbexa | AChE | abx065087 | Mouse Acetylcholinesterase (AChE) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2525 | 1 mg | P21836 | RUO |
Abbexa | AChE | abx065085 | Mouse Acetylcholinesterase (AChE) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P21836 | RUO |
Abbexa | AChE | abx691917 | Mouse Acetylcholinesterase (AChE) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 20 µg | RUO | ||
Abbexa | AChE | abx065086 | Rat Acetylcholinesterase (AChE) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P37136 | RUO |
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