Mouse 3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) Protein

Este producto es parte de ACAA - Acetyl Coenzyme A Acyltransferase
Mouse 3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein ACAA2

proveedor

Abbexa

reference

abx650413

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse ACAA2 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

Acetyl Coenzyme A Acyltransferase 2 (ACAA2), also known as mitochondrial 3-ketoacyl-CoA thiolase, is an essential mitochondrial enzyme involved in the beta-oxidation of fatty acids. It catalyzes the thiolytic cleavage of 3-ketoacyl-CoA into acetyl-CoA, which then enters the TCA cycle for ATP production. ACAA2 is highly expressed in energy-demanding tissues such as the liver, heart, and muscle, where it plays a key role in maintaining metabolic flexibility and energy production during fasting or exercise. Mutations or deficiencies in ACAA2 can impair mitochondrial fatty acid oxidation, leading to conditions such as mitochondrial fatty acid oxidation disorders and myopathies. Beyond its metabolic role, ACAA2 activity influences reactive oxygen species (ROS) production and mitochondrial dynamics, linking it to cellular stress responses and metabolic regulation. Ongoing research explores its potential as a therapeutic target for metabolic diseases and mitochondrial dysfunction.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 36.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg90-Ala397 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ACAA2


dry ice

No


availability

Shipped within 5-7 working days.


alias

DSAEC


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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clonality

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