Mouse 3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) Protein
208€ (10 µg)
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935106861
info@markelab.com
name
Mouse 3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650413
tested applications
WB, SDS-PAGE
Description
Mouse ACAA2 Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Arg90-Ala397 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 36.4 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8BWT1 |
| Gene ID | 52538 |
| Alias | DSAEC |
| Background | Protein ACAA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Acetyl Coenzyme A Acyltransferase 2 (ACAA2), also known as mitochondrial 3-ketoacyl-CoA thiolase, is an essential mitochondrial enzyme involved in the beta-oxidation of fatty acids. It catalyzes the thiolytic cleavage of 3-ketoacyl-CoA into acetyl-CoA, which then enters the TCA cycle for ATP production. ACAA2 is highly expressed in energy-demanding tissues such as the liver, heart, and muscle, where it plays a key role in maintaining metabolic flexibility and energy production during fasting or exercise. Mutations or deficiencies in ACAA2 can impair mitochondrial fatty acid oxidation, leading to conditions such as mitochondrial fatty acid oxidation disorders and myopathies. Beyond its metabolic role, ACAA2 activity influences reactive oxygen species (ROS) production and mitochondrial dynamics, linking it to cellular stress responses and metabolic regulation. Ongoing research explores its potential as a therapeutic target for metabolic diseases and mitochondrial dysfunction.
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