3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx122384
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACAA2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 3-Ketoacyl-CoA Thiolase, Mitochondrial (ACAA2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42765 |
| Gene ID | 10449 |
| NCBI Accession | BC001918 |
| OMIM | 604770 |
| Alias | DSAEC |
| Background | Antibody anti-ACAA2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
Acetyl Coenzyme A Acyltransferase 2 (ACAA2), also known as mitochondrial 3-ketoacyl-CoA thiolase, is an essential mitochondrial enzyme involved in the beta-oxidation of fatty acids. It catalyzes the thiolytic cleavage of 3-ketoacyl-CoA into acetyl-CoA, which then enters the TCA cycle for ATP production. ACAA2 is highly expressed in energy-demanding tissues such as the liver, heart, and muscle, where it plays a key role in maintaining metabolic flexibility and energy production during fasting or exercise. Mutations or deficiencies in ACAA2 can impair mitochondrial fatty acid oxidation, leading to conditions such as mitochondrial fatty acid oxidation disorders and myopathies. Beyond its metabolic role, ACAA2 activity influences reactive oxygen species (ROS) production and mitochondrial dynamics, linking it to cellular stress responses and metabolic regulation. Ongoing research explores its potential as a therapeutic target for metabolic diseases and mitochondrial dysfunction.
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