Mouse A-kinase anchor protein 7 isoform gamma (AKAP7) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for AKAP7
proveedor
Abbexareference
abx501395Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse A-kinase anchor protein 7 isoform gamma (AKAP7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse A-kinase anchor protein 7 isoform gamma concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
AKAP7, also referred to as AKAP15/18, is a small, membrane-associated scaffold protein that localizes PKA and other signaling molecules to the plasma membrane and sarcoplasmic reticulum (SR) in excitable cells, such as neurons and cardiac myocytes. AKAP7 regulates PKA-dependent phosphorylation of L-type calcium channels, ensuring proper calcium influx during action potentials, which is critical for cardiac and neuronal excitability. It also interacts with phospholamban to modulate SR calcium uptake through SERCA2 pumps, impacting cardiac muscle relaxation. AKAP7 isoforms have diverse roles, with AKAP18γ and AKAP18δ being involved in anchoring signaling components to SR and plasma membranes. Dysregulation of AKAP7 impairs calcium handling, leading to arrhythmias, cardiac dysfunction, and impaired synaptic plasticity. AKAP7 has also been implicated in insulin secretion in pancreatic beta cells, where it organizes signaling components involved in glucose-stimulated calcium responses.
Características del producto
category
ELISA Kits
immunogen target
A-kinase anchor protein 7 isoform gamma (AKAP7)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
AKAP7, AKAP18
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AKAP7
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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