Mouse A-kinase anchor protein 7 isoform alpha (AKAP7) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse A-kinase anchor protein 7 isoform alpha (AKAP7) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501393
tested applications
ELISA
Description
Mouse A-kinase anchor protein 7 isoform alpha (AKAP7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse A-kinase anchor protein 7 isoform alpha concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A-kinase anchor protein 7 isoform alpha (AKAP7) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O55074 |
| Gene ID | 432442 |
| Alias | AKAP7, AKAP18 |
| Background | Elisa kits for AKAP7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP7, also referred to as AKAP15/18, is a small, membrane-associated scaffold protein that localizes PKA and other signaling molecules to the plasma membrane and sarcoplasmic reticulum (SR) in excitable cells, such as neurons and cardiac myocytes. AKAP7 regulates PKA-dependent phosphorylation of L-type calcium channels, ensuring proper calcium influx during action potentials, which is critical for cardiac and neuronal excitability. It also interacts with phospholamban to modulate SR calcium uptake through SERCA2 pumps, impacting cardiac muscle relaxation. AKAP7 isoforms have diverse roles, with AKAP18γ and AKAP18δ being involved in anchoring signaling components to SR and plasma membranes. Dysregulation of AKAP7 impairs calcium handling, leading to arrhythmias, cardiac dysfunction, and impaired synaptic plasticity. AKAP7 has also been implicated in insulin secretion in pancreatic beta cells, where it organizes signaling components involved in glucose-stimulated calcium responses.
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