Mouse 5'-Nucleotidase / CD73 (NT5E) Protein (Active)

Pida mas información
935106861
info@markelab.com
Precio
715€ (50 µg)
Protein NT5E
proveedor
Abbexareference
abx691969Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse CD73 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse NT5E (NP_035981.1) without the propeptide, corresponding to the amino acid (Met 1-Lys 549) was expressed, with a C-terminal polyhistidine tag.
Background
The NT5E gene encodes 5'-nucleotidase ecto, also known as CD73, a glycosylphosphatidylinositol (GPI)-anchored enzyme that is crucial in purinergic signaling. It catalyzes the hydrolysis of extracellular nucleotides into nucleosides, with a primary function of converting AMP (adenosine monophosphate) to adenosine. CD73 is expressed on a wide range of cell types, including endothelial cells, epithelial cells, fibroblasts, T cells, and tumor cells. It plays a fundamental role in regulating inflammation, vascular permeability, immune response, and tissue protection under stress conditions such as ischemia. Adenosine generated by CD73 is a potent signaling molecule that binds to adenosine receptors (A1, A2A, A2B, and A3) to mediate various physiological processes, including anti-inflammatory effects, vasodilation, and immunosuppression. In the immune system, CD73 suppresses pro-inflammatory responses and helps in the resolution of inflammation. This dual role makes NT5E a key molecule in both health and disease, especially in pathologies such as cancer, cardiovascular diseases, and chronic inflammatory disorders.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
HEK293 cells
immunogen target
CD73
host
HEK293 cells
form
tested applications
SDS-PAGE
size 1
50 µg
size 2
1 mg
observerd MW
Sequence Fragment: Met1-Lys549 Tag: C-terminal His tag Validity: The validity for this protein is 12 months.
expression
Recombinant
purity
> 95% (SDS-PAGE)
buffer
Lyophilized from sterile PBS, pH 7.4.
storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
or code
NT5E
dry ice
No
availability
Shipped within 5-15 working days.
alias
NT,En,NT5,NTE,eNT,CD73,E5NT,CALJA,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase
NCBI accession
NP_035981.1
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Rat Nt5e(5'-nucleotidase) ELISA Kit

proveedor
FineTestreference
ER0232reactivity
ratstatus
RUOPrecio a consultar
Ver másanti- NT5E/CD73 antibody

proveedor
FineTestreference
FNab05878Tested Applications
ELISA, WB,IHC,FCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalNT5E(5'-nucleotidase) is also named as NT5, NTE,CD73,ecto-5'-nucleotidase, and belongs to the 5'-nucleotidase family. It...
Precio a consultar
Ver másRecombinant Human CD73

proveedor
FineTestreference
P1458Tested Applications
Western Blot, ELISAstatus
RUOPrecio a consultar
Ver más