Mouse 5'-Nucleotidase / CD73 (NT5E) ELISA Kit

Este producto es parte de NT5E - 5'-nucleotidase ecto
Mouse 5'-Nucleotidase / CD73 (NT5E) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for NT5E

proveedor

Abbexa

reference

abx511790

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse 5'-Nucleotidase / CD73 (NT5E) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse 5'-Nucleotidase / CD73 (NT5E) concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

The NT5E gene encodes 5'-nucleotidase ecto, also known as CD73, a glycosylphosphatidylinositol (GPI)-anchored enzyme that is crucial in purinergic signaling. It catalyzes the hydrolysis of extracellular nucleotides into nucleosides, with a primary function of converting AMP (adenosine monophosphate) to adenosine. CD73 is expressed on a wide range of cell types, including endothelial cells, epithelial cells, fibroblasts, T cells, and tumor cells. It plays a fundamental role in regulating inflammation, vascular permeability, immune response, and tissue protection under stress conditions such as ischemia. Adenosine generated by CD73 is a potent signaling molecule that binds to adenosine receptors (A1, A2A, A2B, and A3) to mediate various physiological processes, including anti-inflammatory effects, vasodilation, and immunosuppression. In the immune system, CD73 suppresses pro-inflammatory responses and helps in the resolution of inflammation. This dual role makes NT5E a key molecule in both health and disease, especially in pathologies such as cancer, cardiovascular diseases, and chronic inflammatory disorders.

Características del producto

category

ELISA Kits

immunogen target

5'-Nucleotidase / CD73 (NT5E)

reactivity

Mouse

test range

78 pg/ml - 5000 pg/ml

sensitivity

< 41.3 pg/ml

assay type

Sandwich

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

alias

NT,En,NT5,NTE,eNT,CD73,E5NT,CALJA,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase 

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

NT5E

dry ice

No

uniprot id

https://www.uniprot.org/uniprotkb/Q61503

gene id

https://www.ncbi.nlm.nih.gov/gene/23959

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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reactivity

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clonality

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