Mouse 5-hydroxytryptamine receptor 7 (HTR7) ELISA Kit

Product specifications

ELISA Kits

5-hydroxytryptamine receptor 7 (HTR7)

Mouse

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P32304

15566

HTR7,5-HT7,5-HT7 receptor

Elisa kits for HTR7

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

HTR7 is a serotonin receptor belonging to the G protein-coupled receptor (GPCR) family that activates adenylate cyclase upon binding to serotonin (5-HT), leading to increased cAMP production. It is widely expressed in the central nervous system, including the thalamus, hypothalamus, hippocampus, and the spinal cord, where it regulates critical functions such as mood, circadian rhythms, sleep, and thermoregulation. HTR7 is also expressed in peripheral tissues, including the gastrointestinal tract and vascular smooth muscles, where it modulates gut motility and vascular tone. Dysregulation of HTR7 signaling has been linked to mood disorders such as depression and bipolar disorder, as well as to sleep disturbances and migraine pathophysiology. Additionally, HTR7 has been implicated in inflammatory diseases and neurodevelopmental disorders due to its influence on neuronal connectivity and immune responses. Pharmacologically, selective HTR7 antagonists have demonstrated antidepressant and anxiolytic effects, making the receptor an attractive target for mood disorder therapies. Furthermore, HTR7 has potential roles in the management of pain and migraine, given its regulatory function in the pain processing pathways. Its broad physiological roles underscore its importance in maintaining neurological homeostasis and suggest therapeutic opportunities in both CNS disorders and systemic diseases.

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