Mouse 4-Aminobutyrate Aminotransferase (ABAT) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ABAT
proveedor
Abbexareference
abx650514Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse ABAT Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
4-Aminobutyrate Aminotransferase (ABAT), also known as GABA transaminase, is a mitochondrial enzyme that plays a crucial role in the metabolism of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. ABAT catalyzes the conversion of GABA to succinic semialdehyde, which is subsequently converted to succinate and enters the tricarboxylic acid (TCA) cycle, linking GABA metabolism to energy production. This process is critical for maintaining GABAergic tone and neurotransmitter balance in the brain. Dysregulation of ABAT activity has been implicated in neurological and psychiatric disorders, including epilepsy, anxiety, depression, and schizophrenia, where altered GABA levels contribute to pathophysiology. Mutations in the ABAT gene can result in disorders such as GABA-transaminase deficiency, characterized by severe developmental delays, seizures, and hypotonia. ABAT is also a target for anticonvulsant drugs like vigabatrin, which inhibit its activity to increase GABA levels and reduce neuronal excitability. Beyond its role in the nervous system, ABAT has emerging significance in cancer biology, as its expression is altered in certain tumors, influencing metabolic pathways and tumor progression.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
4-Aminobutyrate Aminotransferase (ABAT)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 33.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile236-Lys500 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABAT
dry ice
No
availability
Shipped within 5-7 working days.
alias
GABA-AT,GABAT,NPD009,GABA transaminase
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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