Mouse 4-Aminobutyrate Aminotransferase (ABAT) Protein

Este producto es parte de ABAT - 4-Aminobutyrate Aminotransferase
Mouse 4-Aminobutyrate Aminotransferase (ABAT) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ABAT

proveedor

Abbexa

reference

abx650514

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse ABAT Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

4-Aminobutyrate Aminotransferase (ABAT), also known as GABA transaminase, is a mitochondrial enzyme that plays a crucial role in the metabolism of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. ABAT catalyzes the conversion of GABA to succinic semialdehyde, which is subsequently converted to succinate and enters the tricarboxylic acid (TCA) cycle, linking GABA metabolism to energy production. This process is critical for maintaining GABAergic tone and neurotransmitter balance in the brain. Dysregulation of ABAT activity has been implicated in neurological and psychiatric disorders, including epilepsy, anxiety, depression, and schizophrenia, where altered GABA levels contribute to pathophysiology. Mutations in the ABAT gene can result in disorders such as GABA-transaminase deficiency, characterized by severe developmental delays, seizures, and hypotonia. ABAT is also a target for anticonvulsant drugs like vigabatrin, which inhibit its activity to increase GABA levels and reduce neuronal excitability. Beyond its role in the nervous system, ABAT has emerging significance in cancer biology, as its expression is altered in certain tumors, influencing metabolic pathways and tumor progression.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

4-Aminobutyrate Aminotransferase (ABAT)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 33.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile236-Lys500 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABAT


dry ice

No


availability

Shipped within 5-7 working days.


alias

GABA-AT,GABAT,NPD009,GABA transaminase


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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