4-Aminobutyrate Aminotransferase (ABAT) Antibody
286€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
4-Aminobutyrate Aminotransferase (ABAT) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx131057
Tested Applications
WB, IHC
Description
4-Aminobutyrate Aminotransferase Antibody is a Rabbit Polyclonal against 4-Aminobutyrate Aminotransferase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 4-Aminobutyrate Aminotransferase (ABAT) Immunogen: ABAT (Ile236-Lys500) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P61922 |
| Alias | GABA-AT,GABAT,NPD009,GABA transaminase |
| Background | Antibody anti-ABAT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
4-Aminobutyrate Aminotransferase (ABAT), also known as GABA transaminase, is a mitochondrial enzyme that plays a crucial role in the metabolism of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. ABAT catalyzes the conversion of GABA to succinic semialdehyde, which is subsequently converted to succinate and enters the tricarboxylic acid (TCA) cycle, linking GABA metabolism to energy production. This process is critical for maintaining GABAergic tone and neurotransmitter balance in the brain. Dysregulation of ABAT activity has been implicated in neurological and psychiatric disorders, including epilepsy, anxiety, depression, and schizophrenia, where altered GABA levels contribute to pathophysiology. Mutations in the ABAT gene can result in disorders such as GABA-transaminase deficiency, characterized by severe developmental delays, seizures, and hypotonia. ABAT is also a target for anticonvulsant drugs like vigabatrin, which inhibit its activity to increase GABA levels and reduce neuronal excitability. Beyond its role in the nervous system, ABAT has emerging significance in cancer biology, as its expression is altered in certain tumors, influencing metabolic pathways and tumor progression.
Productos relacionados
4-Aminobutyrate Aminotransferase (ABAT) Antibody
ABAT Antibody is a Rabbit Polyclonal antibody against ABAT. 4-aminobutyrate aminotransferase (ABAT) is responsible for c…
Ver producto
4-Aminobutyrate Aminotransferase (ABAT) Antibody
4-Aminobutyrate Aminotransferase Antibody is a Rabbit Polyclonal antibody against 4-Aminobutyrate Aminotransferase.…
Ver producto 4-Aminobutyrate Aminotransferase (ABAT) Antibody
4-Aminobutyrate Aminotransferase Antibody is a Rabbit Polyclonal against 4-Aminobutyrate Aminotransferase.…
Ver producto