Motilin Receptor (MTLR) Antibody

Este producto es parte de MLNR - Motilin receptor
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52€ (10 µg)

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935106861
info@markelab.com
name
Motilin Receptor (MTLR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015346
tested applications
WB

Description

Rabbit polyclonal antibody against MTLR protein. Immunogen region is C-terminal.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Motilin Receptor (MTLR)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
WB
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O43193
Alias
MLNR,GRM,GPR38,G protein-coupled receptor 38,MOT-R,MTLR ,MTLR1
Background
Antibody anti-MLNR
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

The motilin receptor (MLNR) is a G protein-coupled receptor (GPCR) primarily expressed in the gastrointestinal tract, where it is activated by motilin, a 22-amino acid peptide hormone. MLNR is predominantly located in the smooth muscle of the stomach and upper small intestine, where it regulates gastrointestinal motility and the migrating motor complex (MMC) during fasting. Activation of MLNR triggers Gq-mediated signaling pathways, leading to increased intracellular calcium levels, smooth muscle contraction, and enhanced peristalsis. MLNR plays a key role in initiating gastric emptying and maintaining gut motility. It is a critical target for prokinetic agents such as erythromycin, which mimic motilin's action to stimulate gastric motility in conditions like gastroparesis. Dysregulation of MLNR is associated with gastrointestinal motility disorders, including delayed gastric emptying and functional dyspepsia. MLNR agonists continue to be explored for therapeutic applications to restore gut motility and improve gastrointestinal function in motility-related disorders.

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