Motilin Receptor (MTLR) Antibody
52€ (10 µg)
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935106861
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name
Motilin Receptor (MTLR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015346
tested applications
WB
Description
Rabbit polyclonal antibody against MTLR protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Motilin Receptor (MTLR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43193 |
| Alias | MLNR,GRM,GPR38,G protein-coupled receptor 38,MOT-R,MTLR ,MTLR1 |
| Background | Antibody anti-MLNR |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The motilin receptor (MLNR) is a G protein-coupled receptor (GPCR) primarily expressed in the gastrointestinal tract, where it is activated by motilin, a 22-amino acid peptide hormone. MLNR is predominantly located in the smooth muscle of the stomach and upper small intestine, where it regulates gastrointestinal motility and the migrating motor complex (MMC) during fasting. Activation of MLNR triggers Gq-mediated signaling pathways, leading to increased intracellular calcium levels, smooth muscle contraction, and enhanced peristalsis. MLNR plays a key role in initiating gastric emptying and maintaining gut motility. It is a critical target for prokinetic agents such as erythromycin, which mimic motilin's action to stimulate gastric motility in conditions like gastroparesis. Dysregulation of MLNR is associated with gastrointestinal motility disorders, including delayed gastric emptying and functional dyspepsia. MLNR agonists continue to be explored for therapeutic applications to restore gut motility and improve gastrointestinal function in motility-related disorders.
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Motilin Receptor (MTLR) Antibody
Rabbit polyclonal antibody against MTLR protein. Immunogen region is C-terminal.
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