Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Antibody

Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Antibody

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935106861

info@markelab.com

Precio

338€ (60 µl)

Antibody anti-MAP2K2

proveedor

Abbexa

reference

abx000638

Tested Applications

WB

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

MAP2K2 Antibody is a Rabbit Polyclonal antibody against MAP2K2. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

WB


purification

Purified by affinity chromatography.


recommended dilution

WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.


size 1

60 µl


size 2

120 µl


size 3

200 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

MAP2K2


dry ice

No


availability

Shipped within 5-10 working days.


NCBI accession

NP_109587.1


note

Concentration: 1 mg/ml -


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