Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Antibody
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935106861
info@markelab.com
Precio
338€ (60 µl)
Antibody anti-MAP2K2
proveedor
Abbexareference
abx000638Tested Applications
WBreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
MAP2K2 Antibody is a Rabbit Polyclonal antibody against MAP2K2. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
WB
purification
Purified by affinity chromatography.
recommended dilution
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
60 µl
size 2
120 µl
size 3
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
MAP2K2
dry ice
No
availability
Shipped within 5-10 working days.
uniprot id
NCBI accession
NP_109587.1
note
Concentration: 1 mg/ml -
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