MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
MAPKAPK5 Antibody is a Goat Polyclonal antibody against MAPKAPK5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5) |
| Host | Goat |
| Reactivity | Human, Mouse |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC, IP |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 8550, 17165, 498183 |
| NCBI Accession | NP_003659.2, NP_620777.1 |
| Background | Antibody anti-MAPKAPK5 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Related Products
MAPKAPK5 antibody
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK(ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6(or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6(or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
Ver Producto
MAP Kinase-Activated Protein Kinase 5 Phospho-Ser93 (MAPKAPK5 pS93) Antibody
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites.
Ver Producto
MAP Kinase-Activated Protein Kinase 5 (MAPKAPK5) Antibody
Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 Antibody is a Rabbit Polyclonal antibody against Mitogen-Activated Protein Kinase-Activated Protein Kinase 5.
Ver Producto