Mitogen-Activated Protein Kinase 1 and 3 Phospho-Thr202/Tyr204 (MAPK1/MAPK3 pT202/pY204) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
MAPK3/MAPK1 (pT202/pY204) Antibody is a Rabbit Polyclonal against MAPK3/MAPK1 (pT202/pY204).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mitogen-Activated Protein Kinase 1 and 3 Phospho-Thr202/Tyr204 (MAPK1/MAPK3 pT202/pY204) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Thr202/Tyr204 |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150 mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P27361, P28482 |
| Background | Antibody anti-MAPK1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Related Products
Mitogen-Activated Protein Kinase 1 Phospho-Thr185/Tyr187 and 3 Phospho-Thr202/Tyr204 (MAPK1 pT185/Y187/MAPK3 pT202/Y204) Antibody
Erk1 (pT202/Y204) / Erk2 (pT185/Y187) Antibody is a Rabbit Polyclonal antibody against Erk1 (pT202/Y204) / Erk2 (pT185/Y187). The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Ver Producto
Mitogen-Activated Protein Kinase 1 and 3 / ERK1/2 (MAPK1/MAPK3) Antibody
Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059.
Ver Producto
Mitogen-Activated Protein Kinase 1 and 3 / ERK1/2 (MAPK1/MAPK3) Antibody
ERK1/2 Antibody detects endogenous levels of total ERK1/2. p42 MAP kinase plays a critical role in the regulation of cell growth and differentiation. Activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters.
Ver Producto