Microtubule Associated Protein 2 (MAP2) Antibody
383.5€ (100 µl)
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935106861
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name
Microtubule Associated Protein 2 (MAP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012065
tested applications
ELISA, FCM
Description
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The exact function of this gene is still unknown. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants of this gene have been described, but the full length nature of some of them has not been determined.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Microtubule Associated Protein 2 (MAP2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11137 |
| Gene ID | 4133 |
| OMIM | 157130 |
| Alias | MAP-2,MAP2A,MAP2B,MAP2C |
| Background | Antibody anti-MAP2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Microtubule-associated protein 2 (MAP2) is a protein primarily found in neurons, where it plays a crucial role in stabilizing microtubules, maintaining cell shape, and supporting dendritic development MAP2 is part of a family of microtubule-associated proteins that bind to microtubules and regulate their stability, thereby contributing to the structural integrity of the cytoskeleton In neurons, MAP2 is essential for dendritic growth and synaptic plasticity, as it helps organize microtubules that extend into dendritic spines, the sites of synaptic connections and communication Dysregulation or loss of MAP2 function is associated with neurodegenerative diseases such as Alzheimer's disease and tauopathies, where disrupted microtubule stability leads to impaired neuronal function and neurofibrillary tangles MAP2 also serves as a marker for dendritic structures in neurons and is important for maintaining the organization of the central nervous system during development and in response to injury
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This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
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