anti- MAP2 antibody
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935106861
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name
anti- MAP2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04976
tested applications
ELISA, WB, IF, IHC
Description
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | microtubule-associated protein 2 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70-85 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P11137 |
| Gene ID | 4133 |
| Alias | MAP-2,MAP2A,MAP2B,MAP2C |
| Background | Antibody anti-MAP2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Microtubule-associated protein 2 (MAP2) is a protein primarily found in neurons, where it plays a crucial role in stabilizing microtubules, maintaining cell shape, and supporting dendritic development MAP2 is part of a family of microtubule-associated proteins that bind to microtubules and regulate their stability, thereby contributing to the structural integrity of the cytoskeleton In neurons, MAP2 is essential for dendritic growth and synaptic plasticity, as it helps organize microtubules that extend into dendritic spines, the sites of synaptic connections and communication Dysregulation or loss of MAP2 function is associated with neurodegenerative diseases such as Alzheimer's disease and tauopathies, where disrupted microtubule stability leads to impaired neuronal function and neurofibrillary tangles MAP2 also serves as a marker for dendritic structures in neurons and is important for maintaining the organization of the central nervous system during development and in response to injury
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anti- MAP2 antibody
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Ver Producto