Microfibrillar-Associated Protein 1 (MFAP1) Antibody

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Description
MFAP1 is a component of the elastin-associated microfibrils. Microfibrils, found either in association with elastin or independently, are an important component of the extracellular matrix of many tissues. MFAP1 is one of a number of proteins demonstrated to be essential for cell division.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Microfibrillar-Associated Protein 1 (MFAP1) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Size 1 | 80 µl |
Size 2 | 400 µl |
Form | Liquid |
Tested Applications | ELISA, WB |
Buffer | PBS containing 0.09% sodium azide. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P55081 |
Alias | AMP |
Background | Antibody anti-MFAP1 |
Status | RUO |
Descripción
MFAP1 is a crucial structural protein that plays an integral role in the assembly and stability of extracellular matrix (ECM) microfibrils. These microfibrils are critical components of connective tissues and are involved in maintaining tissue elasticity and structural integrity, particularly in organs such as the skin, lungs, and blood vessels. MFAP1 interacts with fibrillin and other ECM proteins to support microfibril formation and functionality. Additionally, MFAP1 has been implicated in cellular signaling pathways that regulate tissue repair and development. Emerging research suggests its potential role in disorders associated with connective tissue abnormalities, such as Marfan syndrome. MFAP1’s expression and regulatory mechanisms remain under investigation, with ongoing studies aiming to better understand its contribution to ECM dynamics and associated pathologies.
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