MICA antibody
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | MHC class I polypeptide-related sequence A (MICA) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:3000; IHC: 1:50 - 1:200 |
| Clonality | monoclonal |
| Isotype | IgG1 |
| Clone ID | 3H5 |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q29983 |
| Alias | MHC class I polypeptide-related sequence A (MIC-A),MICA,PERB11.1 |
| Background | Antibody anti-MICA |
| Status | RUO |
| Note | Mol. Weight 43-50 kDa |
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MICA antibody
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
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