MICA antibody

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Product specifications
Category | Primary Antibodies |
Immunogen Target | MHC class I polypeptide-related sequence A (MICA) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | WB: 1:500-1:3000; IHC: 1:50 - 1:200 |
Clonality | monoclonal |
Isotype | IgG1 |
Clone ID | 3H5 |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Protein A+G purification |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB, IHC |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | Q29983 |
Alias | MHC class I polypeptide-related sequence A (MIC-A),MICA,PERB11.1 |
Background | Antibody anti-MICA |
Status | RUO |
Note | Mol. Weight 43-50 kDa |
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Human MICA (MHC class I polypeptide-related sequence A) ELISA Kit
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MICA antibody
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
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