TIMP1 belongs to the TIMP family. The proteins in this family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. TIMP metallopeptidase inhibitor 1, also known as TIMP1, is expressed in various tissues of organisms. It plays a crucial role in regulating the activity of matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases (ADAMs and ADAMTSs). TIMP-1 is also involved in several other biological processes, including the regulation of growth factors, tissue remodeling, inhibition of angiogenesis (the formation of new blood vessels), influencing cell morphology (shape and structure), and stimulating gonadal steroidogenesis
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. El inhibidor 1 de la metalopeptidasa IMP, también conocido como TIMP1, se expresa en varios tejidos de organismos. Desempeña un papel crucial en la regulación de la actividad de las metaloproteinasas de matriz (MMP) y las desintegrina-metaloproteinasas (ADAM y ADAMTS). TIMP-1 también participa en varios otros procesos biológicos, incluida la regulación de factores de crecimiento, la remodelación de tejidos, la inhibición de la angiogénesis (la formación de nuevos vasos sanguíneos), la influencia en la morfología celular (forma y estructura) y la estimulación de la esteroidogénesis
Primary Antibodies
Polyclonal
Human
Metalloproteinase Inhibitor 1 (TIMP1)
Rabbit
Unconjugated
Liquid
ELISA, WB, IHC, IF/ICC, FCM
Purified Rabbit Polyclonal Antibody.
PBS containing 0.09% sodium azide.
80 µl
400 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
TIMP1
No
Shipped within 5-10 working days.
Tissue inhibitor of metalloproteinases 1,EPA,EPO,HCI,CLGI,TIMP,TIMP-1
NP_003245.1
This product is for research use only.
Polyclonal Antibody to Tissue Inhibitors of Metalloproteinase 1 (TIMP1).
212.5€ (100 µl)
Ver másPolyclonal Antibody to Tissue Inhibitors of Metalloproteinase 1 (TIMP1).
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