Metalloproteinase Inhibitor 1 (TIMP1) Antibody

Este producto es parte de TIMP1- Metalloproteinase Inhibitor 1
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221€ (100 µl)

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935106861
info@markelab.com
name
Metalloproteinase Inhibitor 1 (TIMP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104192
tested applications
WB, IHC, IF/ICC

Description

Polyclonal Antibody to Tissue Inhibitors of Metalloproteinase 1 (TIMP1).

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetMetalloproteinase Inhibitor 1 (TIMP1)
HostRabbit
ReactivityMouse
Recommended DilutionWB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
PurificationPurified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1100 µl
Size 2200 µl
Size 31 ml
FormLiquid
Tested ApplicationsWB, IHC, IF/ICC
Buffer0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
AvailabilityShipped within 5-7 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP12032
AliasTissue inhibitor of metalloproteinases 1,EPA,EPO,HCI,CLGI,TIMP,TIMP-1
BackgroundAntibody anti-TIMP1
StatusRUO

TIMP1 is a member of the TIMP family and acts as a natural inhibitor of matrix metalloproteinases (MMPs), which are enzymes that degrade components of the extracellular matrix TIMP1 regulates tissue remodeling, inflammation, and wound healing by inhibiting MMP activity and preventing excessive matrix breakdown It also exhibits anti-apoptotic properties by binding to cell surface receptors and activating survival pathways TIMP1 plays a role in cancer progression where its overexpression can inhibit tumor invasion and metastasis by limiting MMP activity, while paradoxically, it can also promote tumor growth by stimulating cell proliferation and angiogenesis Dysregulation of TIMP1 is observed in diseases such as fibrosis, cardiovascular disease, and chronic inflammatory conditions, where altered MMP activity contributes to tissue damage and remodeling TIMP1’s dual role as a regulator of extracellular matrix turnover and cell signaling makes it a key player in both normal physiological processes and pathological conditions

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