Metalloproteinase Inhibitor 1 (TIMP1) Antibody

Pida mas información

935106861

info@markelab.com

Precio

212.5€ (100 µl)

proveedor

Abbexa

reference

abx104192

Tested Applications

WB, IHC, IF/ICC

reactivity

Mouse

status

RUO

clonality

Polyclonal

Descripción

Polyclonal Antibody to Tissue Inhibitors of Metalloproteinase 1 (TIMP1).

Background

MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. TIMP metallopeptidase inhibitor 1, also known as TIMP1, is expressed in various tissues of organisms. It plays a crucial role in regulating the activity of matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases (ADAMs and ADAMTSs). TIMP-1 is also involved in several other biological processes, including the regulation of growth factors, tissue remodeling, inhibition of angiogenesis (the formation of new blood vessels), influencing cell morphology (shape and structure), and stimulating gonadal steroidogenesis

Background

MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. El inhibidor 1 de la metalopeptidasa IMP, también conocido como TIMP1, se expresa en varios tejidos de organismos. Desempeña un papel crucial en la regulación de la actividad de las metaloproteinasas de matriz (MMP) y las desintegrina-metaloproteinasas (ADAM y ADAMTS). TIMP-1 también participa en varios otros procesos biológicos, incluida la regulación de factores de crecimiento, la remodelación de tejidos, la inhibición de la angiogénesis (la formación de nuevos vasos sanguíneos), la influencia en la morfología celular (forma y estructura) y la estimulación de la esteroidogénesis

Características del producto

clonality

Polyclonal

reactivity

Mouse

immunogen target

Metalloproteinase Inhibitor 1 (TIMP1)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

WB, IHC, IF/ICC

purification

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

size 1

100 µl

size 2

200 µl

size 3

1 ml

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

TIMP1

dry ice

availability

Shipped within 5-7 working days.

alias

Tissue inhibitor of metalloproteinases 1,EPA,EPO,HCI,CLGI,TIMP,TIMP-1

uniprot id

https://www.uniprot.org/uniprotkb/P12032

note

This product is for research use only.

Quizá le pueda interesar

Human Metalloproteinase Inhibitor 1 (TIMP1) Enzyme

proveedor

Abbexa

reference

abx073651

Tested Applications

SDS-PAGE

status

RUO

Human Metalloproteinase Inhibitor 1 (TIMP1) is a recombinant Enzyme produced in HEK-293 cells.

225€ (2 µg)