Metabotropic Glutamate Receptor 5 (GRM5) Antibody
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Description
Metabotropic Glutamate Receptor 5 (GRM5) Antibody is a monoclonal Nanobody expressed in CHO cells for the detection of Human GRM5.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Metabotropic Glutamate Receptor 5 (GRM5) |
| Host | CHO cells |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | VHH-8His-Cys-tag |
| Clone ID | I072 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A/G affinity chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41594 |
| Gene ID | 2915 |
| NCBI Accession | NP_000833.1 |
| Alias | GRM5,GPRC1E,MGLUR5,PPP1R86,mGlu5 |
| Background | Antibody anti-GRM5 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Metabotropic Glutamate Receptor 5 (GRM5) Antibody
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 (also known as GPRC1E) and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM5 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.
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