Merlin (NF2) Antibody (Biotin)
169€ (20 µg)
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Name
Merlin (NF2) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx314256
Tested Applications
ELISA
Description
NF2 Antibody (Biotin) is a Rabbit Polyclonal against NF2 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Merlin (NF2) Immunogen: Recombinant human Merlin protein (230-414AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35240 |
| Gene ID | 4771 |
| NCBI Accession | NP_000259.1, NM_000268.3 |
| OMIM | 607379 |
| Alias | ACN,SCH,BANF,SWNV,merlin-1,Merlin,Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomerlin,Schwannomin |
| Background | Antibody anti-NF2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (NF2) is another critical tumor suppressor protein that functions as part of the NF2 gene, playing a key role in regulating cell-cell contact, maintaining cell adhesion, and controlling cell growth MERLIN, as a homolog of the ERM (ezrin-radixin-moesin) family of proteins, is involved in linking the actin cytoskeleton to the plasma membrane and plays a role in cellular processes such as migration, differentiation, and response to growth signals MERLIN acts as a tumor suppressor by inhibiting uncontrolled cell division and preventing the formation of tumors, particularly in the nervous system, where mutations in NF2 lead to the development of benign tumors known as schwannomas, including vestibular schwannomas, which affect hearing and balance MERLIN’s interaction with other signaling pathways, including the Hippo pathway, further strengthens its role in controlling cell proliferation and apoptosis Dysregulation of MERLIN signaling due to NF2 mutations contributes to the formation of tumors, making NF2 an important gene in the context of cancer research and therapeutic development
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