Mouse Neurofibromin 2 (NF2) Protein
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Description
Recombinant Neurofibromin 2 (NF2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Neurofibromin 2 (NF2) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 37.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp30-Arg311 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46662 |
| Alias | ACN,SCH,BANF,SWNV,merlin-1,Merlin,Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomerlin,Schwannomin |
| Background | Protein NF2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (NF2) is another critical tumor suppressor protein that functions as part of the NF2 gene, playing a key role in regulating cell-cell contact, maintaining cell adhesion, and controlling cell growth MERLIN, as a homolog of the ERM (ezrin-radixin-moesin) family of proteins, is involved in linking the actin cytoskeleton to the plasma membrane and plays a role in cellular processes such as migration, differentiation, and response to growth signals MERLIN acts as a tumor suppressor by inhibiting uncontrolled cell division and preventing the formation of tumors, particularly in the nervous system, where mutations in NF2 lead to the development of benign tumors known as schwannomas, including vestibular schwannomas, which affect hearing and balance MERLIN’s interaction with other signaling pathways, including the Hippo pathway, further strengthens its role in controlling cell proliferation and apoptosis Dysregulation of MERLIN signaling due to NF2 mutations contributes to the formation of tumors, making NF2 an important gene in the context of cancer research and therapeutic development
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