Melanoma Cell Adhesion Molecule (MCAM) Antibody (PE)
585€ (100 tests)
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935106861
info@markelab.com
name
Melanoma Cell Adhesion Molecule (MCAM) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx270979
tested applications
FCM
Description
Melanoma Cell Adhesion Molecule (MCAM) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Melanoma Cell Adhesion Molecule (MCAM) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Melanoma Cell Adhesion Molecule (MCAM) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | Cell surface glycoprotein MUC18,CD146,MUC18,HEMCAM,METCAM,MelCAM,Cell surface glycoprotein P1H12,Melanoma-associated antigen A32,S-endo 1 endothelial-associated antigen |
| Background | Antibody anti-MCAM |
| Status | RUO |
Descripción
The melanoma cell adhesion molecule (MCAM), also known as CD146 or MUC18, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF). MCAM was initially identified as an adhesion molecule highly expressed in melanoma cells, and since then, it has been shown to play a role in various cellular processes beyond melanoma, including angiogenesis, inflammation, and immune cell trafficking. MCAM is expressed in a variety of cell types, such as endothelial cells, smooth muscle cells, and immune cells, contributing to its diverse biological functions. Its key role in cellular adhesion makes it critical in both normal physiological processes like vascular integrity and in pathological conditions such as cancer metastasis, cardiovascular disease, and inflammation.
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