Melanoma Cell Adhesion Molecule (MCAM) Antibody
383.5€ (100 µl)
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Name
Melanoma Cell Adhesion Molecule (MCAM) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015923
Tested Applications
ELISA, WB, IHC, FCM
Description
The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue.Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread.Could be an adhesion molecule active in neural crest cells during embryonic development.Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Melanoma Cell Adhesion Molecule (MCAM) Immunogen: Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 71.6 kDa |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43121 |
| Gene ID | 4162 |
| OMIM | 155735 |
| Alias | Cell surface glycoprotein MUC18,CD146,MUC18,HEMCAM,METCAM,MelCAM,Cell surface glycoprotein P1H12,Melanoma-associated antigen A32,S-endo 1 endothelial-associated antigen |
| Background | Antibody anti-MCAM |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The melanoma cell adhesion molecule (MCAM), also known as CD146 or MUC18, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF). MCAM was initially identified as an adhesion molecule highly expressed in melanoma cells, and since then, it has been shown to play a role in various cellular processes beyond melanoma, including angiogenesis, inflammation, and immune cell trafficking. MCAM is expressed in a variety of cell types, such as endothelial cells, smooth muscle cells, and immune cells, contributing to its diverse biological functions. Its key role in cellular adhesion makes it critical in both normal physiological processes like vascular integrity and in pathological conditions such as cancer metastasis, cardiovascular disease, and inflammation.
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