Melanoma Cell Adhesion Molecule (MCAM) Antibody

Este producto es parte de MCAM - melanoma cell adhesion molecule
Product Graph
292.5€ (80 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Melanoma Cell Adhesion Molecule (MCAM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031695
tested applications
ELISA, WB, IHC

Description

MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Melanoma Cell Adhesion Molecule (MCAM)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P43121
Alias
Cell surface glycoprotein MUC18,CD146,MUC18,HEMCAM,METCAM,MelCAM,Cell surface glycoprotein P1H12,Melanoma-associated antigen A32,S-endo 1 endothelial-associated antigen
Background
Antibody anti-MCAM
Status
RUO

Descripción

The melanoma cell adhesion molecule (MCAM), also known as CD146 or MUC18, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF). MCAM was initially identified as an adhesion molecule highly expressed in melanoma cells, and since then, it has been shown to play a role in various cellular processes beyond melanoma, including angiogenesis, inflammation, and immune cell trafficking. MCAM is expressed in a variety of cell types, such as endothelial cells, smooth muscle cells, and immune cells, contributing to its diverse biological functions. Its key role in cellular adhesion makes it critical in both normal physiological processes like vascular integrity and in pathological conditions such as cancer metastasis, cardiovascular disease, and inflammation.

Related Products

APC-30113

APC Anti-Human CD146 Antibody(AA98)

Ver Producto
EH1880

Human MCAM (Cell surface glycoprotein MUC18) ELISA Kit

Ver Producto
FITC-30113

FITC Anti-Human CD146 Antibody(AA98)

Ver Producto