Melanocyte-Stimulating Hormone Receptor (MC1R) Antibody
260€ (50 µl)
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Name
Melanocyte-Stimulating Hormone Receptor (MC1R) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx212380
Tested Applications
ELISA, WB
Description
MC1R Antibody is a Rabbit Polyclonal against MC1R.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Melanocyte-Stimulating Hormone Receptor (MC1R) Immunogen: Synthetic peptide of human MC1R. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01726 |
| Gene ID | 4157 |
| Alias | MC1R,CMM5,MSH-R,SHEP2,melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
| Background | Antibody anti-MC1R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
MC1R is a G protein-coupled receptor (GPCR) activated by melanocortin peptides, including α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH). It is primarily expressed in melanocytes, where it regulates skin and hair pigmentation by stimulating the production of eumelanin (dark pigment) through the cAMP pathway. MC1R activation increases intracellular cyclic AMP (cAMP), activating protein kinase A (PKA) and leading to the upregulation of melanin synthesis. Variations and mutations in MC1R are associated with pigmentation phenotypes, such as red hair, fair skin, and an increased susceptibility to UV-induced skin damage and melanoma. Beyond pigmentation, MC1R plays roles in anti-inflammatory responses, immune modulation, and DNA repair, where its activation reduces inflammation and oxidative stress. MC1R agonists are being explored as therapeutic options for UV protection, melanoma prevention, and anti-inflammatory therapies. Its multifaceted role in pigmentation, inflammation, and cancer underscores MC1R’s significance as a therapeutic target.
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