Melanocortin receptor 4 (MC4R) Antibody (FITC)
169€ (20 µg)
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935106861
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name
Melanocortin receptor 4 (MC4R) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx336472
Description
MC4R Antibody (FITC) is a Rabbit Polyclonal against MC4R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Melanocortin receptor 4 (MC4R) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32245 |
| Gene ID | 4160 |
| Alias | MC4R,BMIQ20 |
| Background | Antibody anti-MC4R |
| Status | RUO |
Descripción
MC4R is a G protein-coupled receptor activated by melanocortins such as α-MSH and ACTH, primarily expressed in the hypothalamus. MC4R plays a central role in regulating energy homeostasis, appetite suppression, and body weight. Activation of MC4R stimulates Gs proteins, increasing intracellular cAMP levels and activating downstream pathways to inhibit feeding and promote energy expenditure. Mutations in MC4R are the most common cause of monogenic obesity, resulting in hyperphagia and reduced energy expenditure. In addition to its role in metabolism, MC4R influences glucose homeostasis, cardiovascular function, and sexual behavior. MC4R agonists are being developed as potential therapeutics for obesity and related metabolic disorders, while antagonists are explored for cachexia and anorexia. MC4R’s critical role in appetite regulation and energy balance highlights its significance as a target for treating obesity, metabolic syndrome, and weight-related disorders.
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