Melanocortin 3 Receptor (MC3R) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
MC3R Antibody is a Rabbit Polyclonal against MC3R.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Melanocortin 3 Receptor (MC3R) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41968 |
| Gene ID | 4159 |
| NCBI Accession | NP_063941.3 |
| Alias | MC3R,BMIQ9,MC3,MC3-R,OB20,OQTL,γ-MSH receptor,melanocortin receptor 3 |
| Background | Antibody anti-MC3R |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
MC3R is a G protein-coupled receptor activated by melanocortins, including α-MSH, β-MSH, and ACTH. MC3R is expressed primarily in the hypothalamus, pituitary gland, and other peripheral tissues, where it plays a critical role in energy homeostasis, feeding behavior, and circadian rhythms. MC3R signaling involves coupling to Gs proteins, leading to increased cAMP levels and activation of downstream pathways that regulate appetite suppression and energy expenditure. In the hypothalamus, MC3R modulates the activity of neuropeptides, such as AgRP and POMC, balancing food intake and energy utilization. Dysregulation of MC3R has been linked to obesity, metabolic syndrome, and circadian rhythm disorders. MC3R also contributes to immune regulation, influencing anti-inflammatory responses and macrophage function. Emerging evidence highlights its role in skeletal muscle metabolism and cardiovascular function. Therapeutic targeting of MC3R is being explored for obesity treatment, metabolic disorders, and inflammatory conditions, emphasizing its importance in energy balance and homeostatic regulation.
Related Products
Human MC3R(Melanocortin receptor 3) ELISA Kit
Ver Producto
anti- MC3R antibody
Receptor for MSH(alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
Ver Producto
Melanocortin 3 Receptor (MC3R) Antibody
MC3R Antibody is a Rabbit Polyclonal antibody against MC3R. This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008].
Ver Producto