Methyl CpG Binding Protein 2 Phospho-Ser423 (MECP2 pS423) Antibody
292.5€ (80 µl)
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Name
Methyl CpG Binding Protein 2 Phospho-Ser423 (MECP2 pS423) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx032076
Tested Applications
ELISA, WB, IHC
Description
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Methyl CpG Binding Protein 2 Phospho-Ser423 (MECP2 pS423) Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S423 of human MeCP2. |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | WB: 1/500, IHC-P: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 52.4 kDa |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51608 |
| Gene ID | 4204 |
| NCBI Accession | NP_001104262.1, NP_004983.1 |
| OMIM | 105830 |
| Background | Antibody anti-MeCP2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
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