Mast/Stem Cell Growth Factor Receptor Kit (KIT) Antibody (Biotin)
78€ (25 µg)
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Name
Mast/Stem Cell Growth Factor Receptor Kit (KIT) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx228802
Tested Applications
FCM
Description
CD117 antibody (Biotin) is a Rat monoclonal antibody against CD117.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Mast/Stem Cell Growth Factor Receptor Kit (KIT) |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Conjugation | Biotin |
| Isotype | IgG2b |
| Size 1 | 25 µg |
| Size 2 | 100 µg |
| Tested Applications | FCM |
| Buffer | PBS with 0.05% Proclin300, 1% BSA. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P05532 |
| Gene ID | 16590 |
| Alias | Mast/stem cell growth factor receptor Kit,PBT,SCFR,C-Kit,CD117,MASTC,Piebald trait protein (PBT),Proto-oncogene c-Kit,Proto-oncogene c-Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Background | Antibody anti-KIT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The KIT protein, also known as the KIT receptor tyrosine kinase or CD117, is a proto-oncogene that encodes a transmembrane receptor. It plays essential roles in cell growth, survival, migration, and differentiation in several types of cells, especially in hematopoietic stem cells, germ cells, melanocytes, and cells in the gastrointestinal tract. The gene encoding KIT is located on chromosome 4q12 and is highly conserved across species, highlighting its fundamental role in development and cellular homeostasis. KIT is activated by binding to its ligand, stem cell factor (SCF), also known as mast cell growth factor. This binding triggers a cascade of downstream signaling pathways critical for normal cellular processes. However, mutations in KIT can result in its constitutive activation, which is implicated in various diseases, including gastrointestinal stromal tumors (GISTs), systemic mastocytosis, acute myeloid leukemia (AML), and other cancers. As a proto-oncogene, KIT’s aberrant signaling due to mutation can drive tumorigenesis, making it a target for cancer therapies, particularly tyrosine kinase inhibitors (TKIs).
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