Mast/Stem Cell Growth Factor Receptor Kit (KIT) Antibody (APC)

Este producto es parte de KIT - KIT receptor tyrosine kinase ( proto oncogene)
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117€ (20 tests)

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935106861
info@markelab.com
name
Mast/Stem Cell Growth Factor Receptor Kit (KIT) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx229296
tested applications
FCM

Description

CD117 Antibody (APC) is a Human Monoclonal Antibody against CD117.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Mast/Stem Cell Growth Factor Receptor Kit (KIT)
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
APC
Isotype
IgG1 Kappa
Clone ID
A219
Size 1
20 tests
Size 2
100 tests
Size 3
200 tests
Tested Applications
FCM
Buffer
PBS with 0.05% Proclin300, 1% BSA.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P10721
Gene ID
3815
Alias
Mast/stem cell growth factor receptor Kit,PBT,SCFR,C-Kit,CD117,MASTC,Piebald trait protein (PBT),Proto-oncogene c-Kit,Proto-oncogene c-Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Background
Antibody anti-KIT
Status
RUO

Descripción

The KIT protein, also known as the KIT receptor tyrosine kinase or CD117, is a proto-oncogene that encodes a transmembrane receptor. It plays essential roles in cell growth, survival, migration, and differentiation in several types of cells, especially in hematopoietic stem cells, germ cells, melanocytes, and cells in the gastrointestinal tract. The gene encoding KIT is located on chromosome 4q12 and is highly conserved across species, highlighting its fundamental role in development and cellular homeostasis. KIT is activated by binding to its ligand, stem cell factor (SCF), also known as mast cell growth factor. This binding triggers a cascade of downstream signaling pathways critical for normal cellular processes. However, mutations in KIT can result in its constitutive activation, which is implicated in various diseases, including gastrointestinal stromal tumors (GISTs), systemic mastocytosis, acute myeloid leukemia (AML), and other cancers. As a proto-oncogene, KIT’s aberrant signaling due to mutation can drive tumorigenesis, making it a target for cancer therapies, particularly tyrosine kinase inhibitors (TKIs).

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