MAS Related GPR Family Member X3 (MRGPRX3) Antibody
273€ (200 µl)
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935106861
info@markelab.com
name
MAS Related GPR Family Member X3 (MRGPRX3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430806
tested applications
P-ELISA
Description
MRGPRX3 Antibody is a Goat Polyclonal antibody against MRGPRX3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | MAS Related GPR Family Member X3 (MRGPRX3) |
| Host | Goat |
| Recommended Dilution | P-ELISA: 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 117195 |
| NCBI Accession | NP_473372.2 |
| Alias | MRGPRX3,MrgA,Mrgpra,Mrga10,SNSR1,Sensory neuron-specific G protein-coupled receptor 1,GPCR,MRGX3,SNSR1,SNSR2 |
| Background | Antibody anti-MRGPRX3 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
MRGPRX3 is a member of the MAS-related GPR family of receptors, similar in structure and function to MRGPRX1 and MRGPRX2. It is expressed in sensory neurons and mast cells, playing a role in the mediation of allergic responses and pain. MRGPRX3 is activated by various endogenous peptides and is involved in the release of histamine and other mediators from mast cells, contributing to allergic inflammation. It is particularly involved in the sensation of itch and may also play a role in modulating pain sensitivity and neurogenic inflammation. The receptor’s activation leads to the initiation of intracellular signaling cascades that include calcium release and other pro-inflammatory responses. Dysregulation of MRGPRX3 signaling is linked to disorders involving chronic pain, itch, and hypersensitivity. As a potential therapeutic target, MRGPRX3 could be modulated for the treatment of chronic pain conditions, allergic disorders, and inflammatory diseases.
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