Macrophage Scavenger Receptor Types I And II (MSR1) Antibody

Este producto es parte de MSR1 - macrophage scavenger receptor 1
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260€ (50 µg)

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935106861
info@markelab.com
name
Macrophage Scavenger Receptor Types I And II (MSR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx377926
tested applications
ELISA, WB, IHC

Description

Macrophage Scavenger Receptor Types I And II (MSR1) Antibody is a Rabbit polyclonal antibody for the detection of Human Macrophage Scavenger Receptor Types I And II (MSR1).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Macrophage Scavenger Receptor Types I And II (MSR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P21757
Gene ID
4481
NCBI Accession
NP_002436.1
Alias
Macrophage scavenger receptor types I and II,SRA,SR-A,CD204,SR-AI,phSR1,phSR2,SCARA1,SR-AII,SR-AIII,Macrophage acetylated LDL receptor I and II,Scavenger receptor class A member 1
Background
Antibody anti-MSR1
Status
RUO

Descripción

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Macrophage Scavenger Receptor 1 (MSR1) Antibody

MSR1 Antibody is a Rabbit Polyclonal antibody against MSR1. This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008].

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