This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Primary Antibodies
Polyclonal
Human, Mouse
Macrophage Scavenger Receptor 1 (MSR1)
Rabbit
Unconjugated
Liquid
ELISA, WB
Purified through a protein A column, followed by peptide affinity purification.
PBS containing 0.09% sodium azide.
80 µl
400 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
MSR1
No
Shipped within 5-10 working days.
This product is for research use only.
MSR1 Antibody is a Rabbit Polyclonal antibody against MSR1. This gene encodes the class A macrophage scavenger receptors...
175€ (20 µl)
Ver másThis gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by...
250€ (80 µl)
Ver másMSR1 Antibody is a Rabbit Polyclonal antibody against MSR1.
450€ (100 µl)
Ver más