Macrophage Scavenger Receptor 1 (MSR1) Antibody (Biotin)

Este producto es parte de MSR1 - macrophage scavenger receptor 1
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169€ (20 µg)

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935106861
info@markelab.com
name
Macrophage Scavenger Receptor 1 (MSR1) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx314244
tested applications
ELISA

Description

MSR1 Antibody (Biotin) is a Rabbit Polyclonal against MSR1 conjugated to Biotin.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Macrophage Scavenger Receptor 1 (MSR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P21757
Gene ID
4481
NCBI Accession
NP_002436.1, NM_002445.3, NP_619729.1, NM_138715.2
OMIM
153622
Alias
Macrophage scavenger receptor types I and II,SRA,SR-A,CD204,SR-AI,phSR1,phSR2,SCARA1,SR-AII,SR-AIII,Macrophage acetylated LDL receptor I and II,Scavenger receptor class A member 1
Background
Antibody anti-MSR1
Status
RUO

Descripción

Macrophage Scavenger Receptor 1 (MSR1), also known as CD204, is a multifunctional receptor primarily expressed on macrophages and other cells of the mononuclear phagocyte system. MSR1 is a critical player in the immune system, where it recognizes and binds to various ligands, including modified lipoproteins, pathogens, and apoptotic cells, thereby aiding in host defense, tissue homeostasis, and inflammation. MSR1 functions by clearing endogenous and exogenous substances from the bloodstream and tissues, including oxidized low-density lipoproteins (oxLDL), a process essential in preventing atherosclerosis and other inflammatory diseases. Due to its role in these processes, MSR1 has been studied extensively in the context of immune responses, pathogen recognition, and chronic inflammatory conditions, including cardiovascular diseases and cancer.

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MSR1 Antibody is a Rabbit Polyclonal antibody against MSR1. This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008].

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