Lysyl-tRNA Synthetase (KARS) Antibody

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Description
KARS: lysyl-tRNA synthetase. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Lysyl-tRNA Synthetase (KARS) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | IgG1 |
Purification | Unpurified ascites. |
Size 1 | 100 µl |
Form | Liquid |
Tested Applications | ELISA, IHC |
Buffer | Ascitic fluid containing 0.03% sodium azide. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q15046 |
Gene ID | 3735 |
OMIM | 601421 |
Background | Antibody anti-KARS |
Status | RUO |
Note | Concentration: Not determined. - |
Descripción
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Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid(AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate(Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
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