Lysosomal Associated Membrane Protein 3 (LAMP3) Antibody
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Pida mas información
935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-LAMP3
proveedor
Abbexareference
abx030168Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
LAMP3 is a member of a family of membrane glycoproteins. It may change lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells.
Background
Lysosome-associated membrane glycoprotein 3 (LAMP3), also known as DC-LAMP, is a lysosomal membrane protein predominantly expressed in dendritic cells and other immune cells, where it plays a critical role in antigen processing and presentation LAMP3 expression increases during dendritic cell maturation, facilitating the regulation of lysosomal function and endosomal trafficking It is also involved in lysosome-mediated autophagy and immune responses by regulating cellular degradation pathways Dysregulation of LAMP3 has been linked to cancer progression and metastasis, particularly in breast, cervical, and lung cancers, where its overexpression promotes tumor cell survival and invasion through altered lysosomal activity Additionally, LAMP3 has been implicated in hypoxia response pathways, contributing to cellular adaptation to low oxygen environments Emerging studies highlight its role in viral infections, where it can affect viral replication and host immune response, making LAMP3 a potential biomarker for immune regulation and cancer prognosis
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Lysosomal Associated Membrane Protein 3 (LAMP3)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA
purification
Purified through a protein A column, followed by peptide affinity purification.
recommended dilution
Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
LAMP3
dry ice
No
availability
Shipped within 5-10 working days.
alias
CD208,DC LAMP,DC-LAMP,DCLAMP,LAMP,LAMP-3,TSC403,DC-lysosome-associated membrane glycoprotein
uniprot id
NCBI accession
NP_055213.2
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
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