Lysophosphatidic acid receptor 5 (LPAR5) Antibody (Biotin)
260€ (50 µl)
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935106861
info@markelab.com
name
Lysophosphatidic acid receptor 5 (LPAR5) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx343772
tested applications
ELISA
Description
Lysophosphatidic acid receptor 5 (LPAR5) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human LPAR5.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lysophosphatidic acid receptor 5 (LPAR5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H1C0 |
| Gene ID | 57121 |
| Alias | LPAR5,GPR92,GPR93,KPG_010,LPA5,G protein-coupled receptor 92 |
| Background | Antibody anti-LPAR5 |
| Status | RUO |
Descripción
LPAR5 is a G protein-coupled receptor activated by lysophosphatidic acid (LPA), primarily coupling to G12/13 and Gq proteins. It is expressed in the gastrointestinal tract, immune cells, and sensory neurons, where it regulates cellular responses such as migration, cytoskeletal reorganization, and inflammatory signaling. LPAR5 plays a significant role in immune modulation and inflammatory responses by mediating immune cell trafficking and cytokine release. In the gastrointestinal tract, LPAR5 regulates intestinal epithelial cell homeostasis and motility, making it relevant in gut inflammation and tissue repair. Additionally, LPAR5 is implicated in neuropathic pain, where its activation sensitizes sensory neurons, contributing to pain perception. Dysregulation of LPAR5 signaling has been linked to inflammatory diseases, neuropathic pain, and cancer progression, where it enhances tumor cell migration and survival. LPAR5 antagonists are under investigation for therapeutic use in conditions such as inflammatory bowel disease, neuropathic pain, and cancer metastasis, highlighting its potential as a target for immune and inflammatory regulation.
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