Lysophosphatidic acid receptor 3 (LPAR3) Antibody (FITC)
260€ (50 µl)
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Name
Lysophosphatidic acid receptor 3 (LPAR3) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx343767
Description
Lysophosphatidic acid receptor 3 (LPAR3) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human LPAR3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Lysophosphatidic acid receptor 3 (LPAR3) Immunogen: Peptide sequence from Human Lysophosphatidic acid receptor 3 protein (312-330 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purification | Purified by antigen affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBY5 |
| Gene ID | 23566, 65086 |
| Alias | LPAR3,EDG7,Edg-7,GPCR,HOFNH30,LP-A3,LPA3,LPA receptor 3,endothelial differentiation gene 7,lysophosphatidic acid G-protein-coupled receptor 7 |
| Background | Antibody anti-LPAR3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
LPAR3 is a G protein-coupled receptor for lysophosphatidic acid (LPA), widely expressed in reproductive tissues, cardiovascular cells, and epithelial tissues. It signals through Gq, Gi, and G12/13 proteins, activating downstream pathways such as phospholipase C (PLC), MAPK, and Rho/ROCK. LPAR3 plays a crucial role in embryonic development, particularly in implantation, embryo spacing, and uterine function. Dysregulation of LPAR3 impairs fertility and embryonic viability, as evidenced in animal models. In cancer, LPAR3 promotes tumor progression, angiogenesis, and metastasis, particularly in breast, ovarian, and colorectal cancers. LPAR3 activation enhances cancer cell migration and survival, making it a key contributor to cancer aggressiveness. In the cardiovascular system, LPAR3 regulates vascular tone and endothelial cell function, contributing to blood vessel integrity. Dysregulated LPAR3 signaling has been implicated in chronic inflammation, atherosclerosis, and fibrotic diseases. Therapeutic strategies targeting LPAR3 aim to modulate its roles in reproduction, cancer, and inflammatory diseases.
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