Lysophosphatidic Acid Receptor 1 (LPAR1) Antibody (Biotin)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Lysophosphatidic Acid Receptor 1 (LPAR1) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx314208
Tested Applications
ELISA
Description
LPAR1 Antibody (Biotin) is a Rabbit Polyclonal against LPAR1 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Lysophosphatidic Acid Receptor 1 (LPAR1) Immunogen: Recombinant human Lysophosphatidic acid receptor 1 protein (316-364AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92633 |
| Gene ID | 1902 |
| NCBI Accession | NP_001392.2, NM_001401.3 |
| OMIM | 602282 |
| Alias | LPAR1,EDG2,LPA1,VZG1,edg-2,vzg-1,Gpcr26,Mrec1.3,rec.1.3,GPR26,endothelial differentiation gene 2,lysophosphatidic acid G-protein-coupled receptor, 2,LPA receptor 1,lysophosphatidic acid receptor Edg-2 |
| Background | Antibody anti-LPAR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
LPAR1 is a G protein-coupled receptor activated by lysophosphatidic acid (LPA), a bioactive phospholipid involved in diverse cellular processes. LPAR1 is widely expressed in various tissues, including the brain, lungs, and fibroblasts, where it mediates cell proliferation, survival, migration, and cytoskeletal reorganization. LPAR1 couples to multiple G proteins (Gi, Gq, and G12/13), activating pathways such as MAPK, Rho/ROCK, and PI3K/Akt. In fibrosis, LPAR1 signaling promotes fibroblast activation and extracellular matrix deposition, contributing to pulmonary, hepatic, and renal fibrosis. It is also implicated in neuropathic pain, where LPAR1 activation sensitizes pain pathways and amplifies neuronal signaling. In cancer, LPAR1 drives tumor growth, metastasis, and angiogenesis, particularly in breast and lung cancers. Dysregulation of LPAR1 is associated with inflammatory disorders, cancer progression, and fibrosis. LPAR1 antagonists are being developed as potential therapies for fibrotic diseases, neuropathic pain, and cancer, highlighting its role as a key modulator of cell migration and tissue remodeling.
Productos relacionados
LPA Receptor 1 Antibody
LPA Receptor 1 Antibody is a Rabbit Polyclonal antibody against Mouse.…
Ver producto
Human Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit
Human Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Hu…
Ver producto Lysophosphatidic Acid Receptor 1 (LPAR1) Antibody
LPAR1 Antibody is a Rabbit Polyclonal against LPAR1.…
Ver producto