LRRC39 Antibody (Biotin)
169€ (20 µg)
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935106861
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name
LRRC39 Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx308885
tested applications
ELISA
Description
LRRC39 Antibody (Biotin) is a Rabbit Polyclonal against LRRC39 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | LRRC39 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96DD0 |
| Gene ID | 127495 |
| NCBI Accession | NP_001243314.1, NM_001256385.1, NP_001243315.1, NM_001256386.1 |
| Alias | Myosin-interacting M-band-associated stress-responsive protein,Myomasp |
| Background | Antibody anti-LRRC39 |
| Status | RUO |
Descripción
LRRC39 is a muscle-specific protein localized to the sarcomere where it interacts with structural proteins to maintain sarcomeric integrity and stability it is a critical component of the Z-disk and is involved in the organization of myofilaments during muscle contraction studies indicate LRRC39 plays a role in mechanotransduction and the regulation of myocyte architecture and function mutations in LRRC39 have been associated with dilated cardiomyopathy (DCM) and other forms of cardiac dysfunction where its loss disrupts the sarcomeric structure and compromises cardiac contractility animal models deficient in LRRC39 demonstrate impaired cardiac performance and sarcomeric disarray highlighting its importance in cardiac muscle development and maintenance ongoing research focuses on its interactions with sarcomeric proteins such as titin and its potential as a therapeutic target for inherited and acquired cardiomyopathies
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