Leucine-Rich Repeat-Containing Protein 39 (LRRC39) Antibody

Product specifications

Primary Antibodies

Leucine-Rich Repeat-Containing Protein 39 (LRRC39)

Rabbit

Human

WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified through a protein A column, followed by peptide affinity purification.

80 µl

400 µl

Liquid

ELISA, WB

PBS containing 0.09% sodium azide.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q96DD0

Myosin-interacting M-band-associated stress-responsive protein,Myomasp

Antibody anti-LRRC39

RUO

Descripción

LRRC39 is a muscle-specific protein localized to the sarcomere where it interacts with structural proteins to maintain sarcomeric integrity and stability it is a critical component of the Z-disk and is involved in the organization of myofilaments during muscle contraction studies indicate LRRC39 plays a role in mechanotransduction and the regulation of myocyte architecture and function mutations in LRRC39 have been associated with dilated cardiomyopathy (DCM) and other forms of cardiac dysfunction where its loss disrupts the sarcomeric structure and compromises cardiac contractility animal models deficient in LRRC39 demonstrate impaired cardiac performance and sarcomeric disarray highlighting its importance in cardiac muscle development and maintenance ongoing research focuses on its interactions with sarcomeric proteins such as titin and its potential as a therapeutic target for inherited and acquired cardiomyopathies

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