Low Sample Volume Rat Bile Acid Receptor (NR1H4) ELISA Kit
897€ (96 tests)
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935106861
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name
Low Sample Volume Rat Bile Acid Receptor (NR1H4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx571616
tested applications
ELISA
Description
Rat Bile Acid Receptor (NR1H4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Bile Acid Receptor (NR1H4) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Farnesoid X Receptor (FXR)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Bile Acid Receptor (NR1H4) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | BAR,FXR,HRR1,HRR-1,PFIC5,RIP14,Bile acid receptor,Farnesoid X-activated receptor,Nuclear receptor subfamily 1 group H member 4 |
| Background | Elisa kits for NR1H4 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Nuclear receptor subfamily 1 group H member 4 (NR1H4), also known as FXR (farnesoid X receptor), is a nuclear receptor that plays a crucial role in regulating bile acid metabolism, liver function, and glucose homeostasis NR1H4 is expressed primarily in the liver, intestine, and kidneys, where it regulates the synthesis, transport, and catabolism of bile acids, which are essential for digestion and the absorption of fats FXR also influences lipid and glucose metabolism, helping maintain energy balance and insulin sensitivity in the liver and other metabolic tissues It plays a key role in protecting the liver from bile acid toxicity by regulating the expression of genes involved in bile acid homeostasis Dysregulation of FXR signaling has been associated with liver diseases such as non-alcoholic fatty liver disease (NAFLD), cirrhosis, and cholestasis, as well as metabolic diseases like obesity and diabetes FXR has emerged as a therapeutic target for managing liver diseases, metabolic syndrome, and conditions related to bile acid imbalances, making it an important receptor for drug development in these areas
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