Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B) Antibody (HRP)

Product specifications

Primary Antibodies

Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B)

Rabbit

Human

Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

HRP

IgG

> 95%

Purified by Protein G chromatography.

20 µg

50 µg

100 µg

200 µg

1 mg

Liquid

ELISA

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

O75015

2215

CD16,FCG3,CD16A,CD16b,FCGR3,CD16-I,FCGR3A,FCR-10,FCRIII,FCRIIIb,Low affinity immunoglobulin gamma Fc region receptor III-B,Fc-gamma RIII-beta,IgG Fc receptor III-1

Antibody anti-FCGR3B

RUO

Descripción

FCGR3B, or Fc gamma receptor IIIb, is a low-affinity receptor for the Fc portion of immunoglobulin G (IgG) antibodies, primarily expressed on neutrophils. It is a member of the Fc gamma receptor (FcγR) family, which plays a pivotal role in mediating immune responses through the recognition of the Fc region of IgG antibodies. FCGR3B is one of the two isoforms of FcγRIII, the other being FCGR3A (CD16A). While both isoforms share sequence similarity and belong to the same gene family, they have distinct tissue distributions, membrane anchoring mechanisms, and functional roles in the immune system. FCGR3B is especially important for facilitating immune complex clearance, phagocytosis, and neutrophil activation, processes that are crucial in maintaining immune homeostasis and defending against pathogens. Dysregulation of FCGR3B or mutations in its gene have been associated with a range of clinical conditions, including autoimmune diseases and chronic inflammatory disorders

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