Human Fc Fragment Of IgG Low Affinity IIIb Receptor (FCGR3B) Protein

Background

FCGR3B, or Fc gamma receptor IIIb, is a low-affinity receptor for the Fc portion of immunoglobulin G (IgG) antibodies, primarily expressed on neutrophils. It is a member of the Fc gamma receptor (FcγR) family, which plays a pivotal role in mediating immune responses through the recognition of the Fc region of IgG antibodies. FCGR3B is one of the two isoforms of FcγRIII, the other being FCGR3A (CD16A). While both isoforms share sequence similarity and belong to the same gene family, they have distinct tissue distributions, membrane anchoring mechanisms, and functional roles in the immune system. FCGR3B is especially important for facilitating immune complex clearance, phagocytosis, and neutrophil activation, processes that are crucial in maintaining immune homeostasis and defending against pathogens. Dysregulation of FCGR3B or mutations in its gene have been associated with a range of clinical conditions, including autoimmune diseases and chronic inflammatory disorders