Long-Chain-Fatty-Acid-CoA Ligase 6 (ACSL6) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Long-Chain-Fatty-Acid-CoA Ligase 6 (ACSL6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014555
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against ACSL6 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Long-Chain-Fatty-Acid-CoA Ligase 6 (ACSL6) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKU0 |
| Alias | ACS2,FACL6,LACS 6,LACS2 |
| Background | Antibody anti-ACSL6 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ACSL6 is a long-chain acyl-CoA synthetase that preferentially activates polyunsaturated fatty acids, such as docosahexaenoic acid (DHA) and arachidonic acid, by converting them into acyl-CoA derivatives. It is predominantly expressed in the brain, erythrocytes, and testes, where it supports specialized lipid metabolism required for neuronal function, erythrocyte membrane integrity, and spermatogenesis. In the brain, ACSL6 plays a crucial role in synthesizing and maintaining membrane lipids enriched with polyunsaturated fatty acids, which are essential for synaptic plasticity and neuronal communication. Dysregulation of ACSL6 has been linked to neurodegenerative diseases, such as schizophrenia and bipolar disorder, as well as hematological disorders due to its involvement in erythrocyte lipid composition. Its activity underscores its importance in maintaining cellular lipid homeostasis, particularly in tissues with high polyunsaturated fatty acid content.
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