Linker For Activation of T-Cells Family, Member 2 (LAT2) Antibody
351€ (100 µg)
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Name
Linker For Activation of T-Cells Family, Member 2 (LAT2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx376272
Tested Applications
ELISA, WB
Description
Linker For Activation of T-Cells Family, Member 2 (LAT2) Antibody is a Rabbit Polyclonal antibody against Linker For Activation of T-Cells Family, Member 2 (LAT2).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Linker For Activation of T-Cells Family, Member 2 (LAT2) Immunogen: Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UHI5 |
| Gene ID | 23428 |
| Alias | LAT2,LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046 |
| Background | Antibody anti-LAT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Linker for activation of T-cells family member 2 (LAT2), also known as NTAL (Non-T cell Activation Linker), is an adaptor protein expressed in various immune cells, including B cells, mast cells, and NK cells. LAT2 functions analogously to LAT by facilitating signal transduction from immunoreceptors, such as the B-cell receptor (BCR) and Fc receptors, to downstream signaling cascades. Upon receptor engagement, LAT2 undergoes tyrosine phosphorylation, enabling it to recruit signaling molecules, such as Grb2 and PLCγ, which are essential for calcium mobilization and activation of the MAPK pathway. LAT2 plays a crucial role in immune responses, particularly in B-cell activation, mast cell degranulation, and cytokine production. Unlike LAT, LAT2 exhibits a broader expression pattern and participates in both adaptive and innate immunity. Its dysregulation has been implicated in allergic reactions and immune cell hyperactivity, making it a potential therapeutic target in allergic and inflammatory diseases.
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